Botany Ajuga integrifolia is a low herb covered with soft hairs, with erect, ascending stems which arise from the rootstock, branching usually diffusely from the base and measuring 10 to 20 centimeters in length. The flowers are arranged in false whorls on the stem apexes. canescens Benth. Steud. Medical Information Search. Oral pharmacokinetic studies in hamsters revealed that the animals tolerated the treatment as no peculiarities in their behavior were observed. crenata (Hochst. Again these uses are variously transmitted down the centuries, until the external applications disappear by the 18th century. (Labiatae) two compounds, jodrellins A (185) (0.005% of dry weight of plant) and B (186) (0.023% by weight, also in S. galericulata), which are the most active clerodane antifeedants isolated so far.340 The extra C-2 to C-19 oxygen link seems to increase the antifeedant activity of the jodrellins relative to clerodin. In vitro pharmacological studies have been conducted on constituents of A. remota of which some of them displayed a concentration-dependent inhibition of chloroquine-sensitive and -resistant Plasmodium falciparum and Mycobacterium tuberculosis. Pronunciation of Ajuga reptans with 1 audio pronunciation, 2 synonyms, 2 meanings, 3 translations, 1 sentence and more for Ajuga reptans. It significantly lowered plasma levels of TG by 45%, TC by 41% and glycerol by 37%, accompanied by increase in HDL-C/TC ratio by 48% at the dose of 25 mg/kg body-wt of hamster. They have been isolated from various genera belonging to different families of plants especially Polyalthia, Acritopappus, Premna, Clerodendron, Ajuga, Teucrium, Salvia, Croton, and Bacchari [226–228]. Finally, there is a range of external uses to which betony has been put. Translation of ajuga remota in Amharic. Ryanodane diterpenes are compounds that are structurally related to the known insecticide ryanodine (see Section3.09.2.10). Ajuga ( / ə ˈ dʒ uː É¡ ə /), [3] also known as Bugleweed, [4] Ground pine [5] or Carpet bugle, is a genus of about 40–50 species of annual and perennial herbaceous flowering plants in the mint family Lamiaceae, with most species native to Europe, Asia, [6] and Africa, but also two species in southeastern Australia. From the leaves of Cornutia grandifolia were isolated two clerodanes, cornutin A (189) (0.083%) and cornutin B (190) (0.144%).347 When 330 ppm of either compound was applied to rye flakes, only one-third as many of them were picked up by the ants as were taken of the controls. Figure 1.17. Some bioactive monoterpenes identified in African medicinal plants. (2.4) and obacunone from Dictamnus dasycarpus Turcz. It has been advocated for gastrointestinal, urinary, gynaecological, respiratory, musculoskeletal and skin problems. Matkowski & Piotrowska (2006) included Stachys officinalis in their research into the antioxidant activity of several medicinal herbs. The other strand to betony's former reputation for joint problems commences with the treatment by internal administration for hip pains in Dioscorides and Galen, which are duly transmitted, sometimes as sciatica, by the Renaissance herbalists (see the discussion of hip pain under ground ivy, Chapter 18). Several ryanodane diterpenes, including ryanodol, cinnzeylanol, cinnzeylanone, and cinnzeylanine, have been isolated from the Macaronesian paleoendemism Persea indica (Lauraceae).64,65 Ryanodol and didehydroryanodol, in contrast to ryanodine and didehydroryanodine, have low toxicity to mice and limited activity at the mammalian ryanodine receptor but are potent knockdown agents for injected houseflies or cockroaches, suggesting a possible difference in the target sites of mammals and insects.66 The antifeedant activity of these compounds has been evaluated, showing the importance of the 11-hemiketal group for the antifeedant effects of ryanodane diterpenes. Ley’s group have isolated from Scutellaria woronowii (Juz.) Michel Kenne Tchimene, ... Victor Kuete, in Medicinal Plant Research in Africa, 2013. Treatment and control of malaria have become more difficult with the spread of drug-resistant parasites and insecticide-resistant mosquito vectors. Applied with salt, it can heal sinuous and burrowing ulcers. They were obtained from the leaves of Ajuga remota (Labiatae), with ajugarin I in 0.05% yield. The antidiabetic activity was studied by (El-Hilaly and Lyoussi, 2002; El-hilaly et al., 2007; Hamden et al., 2008), who confirm the hypoglycemic effect in streptozotocin and alloxan induced diabetic rats, supporting its traditional use in the treatment of diabetes. It is used orally and locally to stop bleeding. ajuga. =Ajuga integrifolia var. crenata Hochst. 2007, Israili and Lyoussi 2009; Rharrabe et al. The in vitro inhibition of one standard strain and 15 clinical isolates of Helicobacter pylori was tested using methanol and water extracts of 80 herbs, including 10 Stachys species wild collected in Greece. ex Vatke =Ajuga remota Benth. Pharmacological studies proving the antidiabetic effect of Ajuga iva (L.) Schreb. The study further indicated rapid gastro-intestinal absorption of 40 maintaining prolonged levels in systemic circulation [248]. f. (2.3), and asiatic acid from Centella asiatica (L.) Urb. This study aimed at investigating the in vivo antiplasmodial activity of crude extract of the leaves of Ajuga remota together with its safety in mice models. In this state-of-the-art review, A. remota as a possible therapeutic tool for malaria is discussed. canescens (Benth.)Cufod. In a recent study, 40 was shown to be the major active constituent of P. longifolia, responsible for its lipid lowering properties by us. Stachys alopecuros was included in the 13 most useful herbs alongside three species of Origanum but the position of Stachys officinalis was not given (Stamatis et al 2003). Macer proposes the herb for all recent wounds and Miller adds the drawing of splinters to wound healing. Ajuga iva (L.,) Schreb., belongs to the Lamiaceae family and the genus of Ajuga (Israili and Lyoussi, 2009). genus Ajuga synonyms, genus Ajuga pronunciation, genus Ajuga translation, English dictionary definition of genus Ajuga. The chemical analysis of the extracts from different parts of A. iva revealed the presence of various bioactive compounds belonging to several phytochemical classes such as flavonoids, terpenoids, steroids and fatty acids (Taleb-Senouci et al., 2009; Aly et al., 2011; Bakrim et al., 2014; Boudjelal et al., 2015; Bendif et al., 2017; Chouitah et al., 2017). It treats the organs of special sense and has had a limited use in problems of the nervous system, before becoming a special cephalic remedy for a variety of nervous problems. The larvae feed on crucifers, but the adults avoid them and feed on the leaves of Clerodendron trichotomum (Verbenaceae), thereby absorbing and sequestering 8 mg per fly of clerodendrin A (175), which makes their surface very bitter and apparently acts to protect them from predators such as birds and lizards (Section 8.05.6.8).344. Define genus Ajuga. It is cited as used in the treatment of diabetes by Algerian ethnobotanical studies (Allali et al., 2008; Boudjelal et al., 2013; Kemassi et al., 2014; Miara et al., 2013). The antioxidant effect has been proven only by Algerian pharmacological studies (Bouderbala et al., 2008, 2010; Chenni et al., 2007; Taleb-Senouci et al., 2009). Ajuga remota is the most frequently used medicinal herb for malaria treatment in Kenya. Additionally, terpenes from medicinal plants have the competency, within what could be termed a “protective window dose”, to protect neurons against β-amyloid peptide, glutamate, NO, oxygen and glucose deprivation and other toxic stimuli by hindering apoptosis by targeting numerous kinases, boosting the clearance of reactive oxygen species (ROS) and protecting the mitochondrial intergrity as described in this chapter. The leaves of Ajuga remota benth have been utilized traditionally for the treatment of patients with diabetes mellitus. From the structure activity analysis it was deduced that trans-decalin system incorporating C-3 olefinic bond accompanied by a butenolide ring in the side chain are essential features for the molecule to exhibit antidyslipidemic activity. 8-O-Acetylharpagide, isolated for the first time from the east African A. remota, did not exhibit any antiplasmodial activity even at the highest concentration of about 500 µM used against the chloroquines-sensitive strain of P. falciparium (FCA20/GHA). The same compound was much less active against S. littoralis (300 ppm on leaf disks of Ricinus communis) or S. exempta (100 ppm on leaf disks of Zea mays).336 The ajugarins have the same enantiomeric configuration, but are slightly different in structure from the clerodins, having a butenolide ring instead of the two fused tetrahydrofuran rings. It showed potent antileishmanial activity against L. donovani, inhibiting DNA topoisomerase I with the induction of apoptosis [239]. (1830) =Ajuga bracteosa var. 2007). It was found that 40 showed a maximum HMGR inhibition of 78.03% at 100 μM in the in vitro experiments. A large number of compounds have already been isolated from A. remota, including ergosterol-5,8-endoperoxide (6), ajugarin-I (1), 8-O-acetylharpagide (5) and several phytoecdysteroids. Ajuga remota in particular is traditionally used as a herbal remedy for fever and infections, and is prescribed for malaria by 66% of the Kenyan herbalists. These indications are once again passed down in full or in part through the Renaissance writers as far as Culpeper before disappearing. A large number of compounds have already been isolated from A. remota , including ergosterol-5,8-endoperoxide ( 6 ), ajugarin-I ( 1 ), 8- O -acetylharpagide ( 5 ) and several phytoecdysteroids. The docking analysis revealed that Ergosterol 5,8 endoperoxide derived from Ajuga remota, have the best binding interaction with protein targets compared with other ingredients and standard drugs. The activity profile shown by 40 was much better than the standard drug lovastatin at the same testing dose. These may have some relevance to the differential diagnosis and treatment of head pain and sinusitis. Human translations with examples: ajuga, bugle, ajugas, bugles, ajuga l, ajuga reptans. Eighty-three patients with chronic cholecystitis and cholangitis received stachyglen (total flavonoids from the herb Stachys neglecta) for 3–4 weeks and it was found that stachyglen exerts a choleretic effect (Peleshchuk et al 1974). Select a category... Ajuga Trustees Checklist Internet Governing Board Crowns Knowledge Bases Soil Fungi Water Supply Plant Leaves Nurseries Schools, Nursery Harmful Algal Bloom Flowers Nurseries, Hospital Cacao Dictionaries, Medical Dictionaries as Topic Dictionaries, Chemical Dictionary Terminology as Topic Dictionaries, Pharmaceutic Potentilla … Evaluation of the diuretic activity of the aqueous and 80% methanol extracts of Ajuga remota Benth (Lamiaceae) leaves in mice. (2015) gave a concise total synthesis of 40 by constructing the stereocenters selectively using organo cuprates or tertiary carbon radical [246]. ajuga remota - ትርጉም Toggle navigation አቢሲኒካ መዝገበ ቃላት Table 1.1. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Clerodane diterpenes are an important diverse class of secondary metabolites characterized by a bicyclic decalin ring system. Another interesting feature of terpenes described in this chapter is their compelling ability, within a “trophic window zone”, to induce the sprouting of neurites and even the growth of neurons, thus suggesting a possibility to put an end to ALS, to treat spinal injuries and to replenish neuronal population in loci of neurodegeneration. crenata Hochst. Contextual translation of "ajuga" into English. Translation of አርማጉሳ in English. It should not be forgotten as a herb for respiratory catarrh, while its virtue as a diuretic and urinary herb and with regard to hypertension, prohibition in pregnancy, or its true effects on the bowel should be subject to further testing, including, where ethical, clinical trials. None of these points is listed in the Old English Herbarium. Abdelhakim Bouyahya, ... Imane Chamkhi, in Journal of Ethnopharmacology, 2020. was confirmed in alloxan (150 mg/kg BW) rat model of diabetes also by (Boudjelal et al., 2015). Tables of 1H and 13C NMR data on a large number of clerodanes are recorded, together with mass spectral data,341 nuclear Overhauser effects, and crystallographic data.342,343, The chlorinated clerodanes tafricanins A (187) and B (188) were isolated from Teucrium africanum (Labiatae), and their structures determined by X-ray methods.344 Tafricanin B is as active as clerodin against Locusta, but tafricanin A is only weakly active. Noun 1. genus Ajuga ... Ajuga remota benth. In a streptozotocin animal model, A. nipponensis had the best effect, decreasing postprandial blood glucose concentrations and inhibiting α-glucosidase and glucose uptake (Hsieh et al., 2014). It is invasive in parts of North America. Synonym(s) Heterotypic =Ajuga bracteosa var. Dioscorides too notes the use of betony for bites of wild animals, as does Galen, but the former also countenances the herb neutralizing deadly poisons. Translation for 'ajuga' in the free English-Dutch dictionary and many other Dutch translations. Azucena Gonzalez-Coloma, ... Braulio M. Fraga, in Comprehensive Natural Products II, 2010, Clerodane diterpenoids have been found in hundreds of plant species from a number of different families. In this study, rats were divided into six groups: control normal group, diabetic control, diabetic rats treated with glibenclamide, diabetic rats treated with Ajuga iva (L.) Schreb. They accumulate in various plant organs such as flowers, stems, leaves, roots and fruits, usually present in small quantities of the order of 0.01–0.1% of the plant dry weight. The hypoglycemic effect of the aerial part of Ajuga iva (L.) Schreb. In feeding bioassays with Spodoptera litura, 3.6 ppm of clerodin causes 50% inhibition of feeding, and with Spodoptera littoralis 50 ppm causes complete inhibition,337 but the greatest single species activity listed is for the compound ajugarin I (179),338 with 80–100% feeding inhibition for Schistocerca gregaria at 0.06 ppm. Establishing the safety of traditional herbal medicines, along with identifying their active principles, are essential steps in the production of a properly standardized and accessible herbal medicine. Although several approaches have been reported for the synthesis of clerodane and related diterpenes [241–243], but only three describe the synthesis of 40. Ajuga remota is the most frequently used medicinal herb for malaria treatment in Kenya. Internally, 1 drachm (4 g) of the leaves infused in 4 cyathi (180 mL) of hot water draws down through the lower organs that blood whose vapours rise back to pour into the eyes while the leaves of this herb eaten will sharpen the sight. How to say Ajuga reptans in English? bab.la arrow_drop_down bab.la - Online dictionaries, vocabulary, conjugation, grammar Toggle navigation Synonyms for ajugas in Free Thesaurus. The corolla may be dark blue, light blue, purple, or yellow and has a very short upper lip. It is an herbaceous flowering plant, in the mint family, native to Europe. (2.4). The leaves of the ajuga hold close together, which keeps them nice and short. A. iva is distributed in the North African and South European countries (Israili and Lyoussi, 2009). Although the compounds tested here were significantly less active than the standard drug chloroquine (IC50 of 0.036 µM), it is interesting to note that (3R*,4S*,5E,7Z)-3,4,-dichloro-7-(dichloromethyl)-3-methylocta-1,5,7-triene and (3R*,4S*,5E,7Z)-3,4,8-trichloro-7-(dichloromethyl)-3-methylocta-1,5,7-triene containing the 7-dichloromethyl moiety were the most active (IC50 of 16 and 17 µM, respectively) [79] (Table 1.1). Ajuga iva (L.) Schreb. Macer mentions cough only. Only the cardiovascular system is not mentioned, but this could be related to the lack of understanding of diseases of the heart and circulation before the mid 18th century. Can produce a striking display ) twice daily for 15 days in.... Of Elsevier B.V. or its licensors or contributors are perennial or annual herbs with leaves..., 2020 in false whorls on the basis of the aerial parts of iva! Plant Research in Africa, 2013 )., deoxygedunin from Azadirachta indica A. Juss betony... 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